Committee on Toxicity of Chemicals in Food, Consumer Products and the Environment

COMMITTEE ON TOXICITY OF CHEMICALS IN FOOD, CONSUMER PRODUCTS AND THE ENVIRONMENT Statement on potential risks from acrylamide in the diet of infants and young children

1. The Scientific Advisory Committee on Nutrition (SACN) is undertaking a review of scientific evidence that will inform the Government’s dietary recommendations for infants and young children. The SACN is examining the nutritional basis of the advice. The Committee on Toxicity in Food, Consumer Products and the Environment (COT) was asked to review the risks of toxicity from chemicals in the d...

TOX/2009/38 COMMITTEE ON TOXICITY OF CHEMICALS IN FOOD, CONSUMER PRODUCTS AND THE ENVIRONMENT Methylglyoxal

Committee on Toxicity of Chemicals in Food, Consumer Products and the Environment Cot Statement on Physiologically Based Pharmacokinetic Modelling

1. In February 2003 the Committee on Toxicity of Chemicals in Food, Consumer Products and the Environment (COT) hosted a workshop on physiologically based pharmacokinetic (PBPK) modelling. The workshop comprised several presentations; these considered the use of PBPK models in risk assessment, requirements for PBPK models and parameters for incorporation of PBPK methods into risk assessment. Th...

COMMITTEE ON TOXICITY OF CHEMICALS IN FOOD, CONSUMER PRODUCTS AND THE ENVIRONMENT Methylglyoxal

2. MG and other products of glycolysis have been shown to produce adducts in both DNA and proteins and elevated levels of these adducts have been associated with aging and disease processes linked with diabetes, renal failure, Alzheimer’s disease and cancer. MG also has a role in the formation of reactive oxygen species (ROS) and stable advanced glycation end-products (AGE’s) (see mechanism of ...

Scientific Committee on Health and Environmental Risks SCHER Scientific Committee on Consumer Products SCCP Scientific Committee on Emerging and Newly Identified Health Risks SCENIHR Risk assessment methodologies and approaches for genotoxic and carcinogenic substances

Genotoxic and carcinogenic substances 2 Three independent non-food Scientific Committees provide the Commission with the scientific advice it needs when preparing policy and proposals relating to consumer safety, public health and the environment. The Committees also draw the Commission's attention to the new or emerging problems which may pose an actual or potential threat. SCHER Questions rel...

JOINT STATEMENT Timing of introduction of gluten into the infant diet

1. In 2010, the Department of Health and Food Standards Agency asked the Scientific Advisory Committee on Nutrition (SACN) and the Committee on Toxicity of Chemicals in Food, Consumer Products and the Environment (COT) to assess the evidence on timing of introduction of gluten into the infant diet and subsequent risk of developing coeliac disease or type 1 diabetes mellitus (T1DM). The request ...